Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide
US6953861B2 · kind B2 · utility
1Cited by
8References
7Claims
0Family size
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Key dates
| Filing date | Mar 18, 2004 |
| Grant date | Oct 11, 2005 |
| Priority date | — |
| Expiry date | Mar 18, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pyrrolidine compounds of the general structure: where n is an integer 1-6 and R is hydrogen or a C1 to C6 straight chain or branched alkyl group, and wherein when n=1, R=CH3 or H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.