Patent · US Expired

11β-Substituted 19-nor-17-α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring

US6956031B2 · kind B2 · utility

5Cited by

0References

17Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Alexander Hillisch · Solingen, DE
Walter Elger · Berlin, DE
Rolf Bohlmann · Berlin, DE
Jens Hoffmann · Mühlenbeck, DE

Key dates

Filing date	Mar 27, 2003
Grant date	Oct 18, 2005
Priority date	—
Expiry date	Dec 10, 2023

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J17/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II in which R11 is a long-chain alkyl radical that has a nitrogen atom that can be substituted in terminal position with a perfluoroalkyl group. The compounds act in a tissue-selective manner as pure antiestrogens and are suitable for the production of pharmaceutical agents because of these properties.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.