Inhibitors of complement activation

US6956107B2 · kind B2 · utility

Assignee

• TANOX, INC. · US

Inventors

• Michael S. C. Fung · Houston, US
• William Sun · Bellaire, US
• Cecily R. Y. Sun · Bellaire, US

Key dates

• Filing date: Mar 29, 2001
• Grant date: Oct 18, 2005
• Expiry date: Mar 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.