Patent · US Expired

Polysaccharide-polypeptide conjugate

US6956119B2 · kind B2 · utility

1Cited by

4References

19Claims

0Family size

Assignee

Hans Loibner · AT

Inventors

Hans Loibner · Wien, AT
Helmut Eckert · Simmerath, DE

Key dates

Filing date	Mar 21, 2001
Grant date	Oct 18, 2005
Priority date	—
Expiry date	Mar 22, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/646
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.