Monofunctional polyethylene glycol aldehydes
US6956135B2 · kind B2 · utility
11Cited by
8References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2003 |
| Grant date | Oct 18, 2005 |
| Priority date | — |
| Expiry date | Feb 11, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L2203/02
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.