Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex
US6957150B2 · kind B2 · utility
0Cited by
2References
56Claims
0Family size
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Key dates
| Filing date | Jan 25, 2001 |
| Grant date | Oct 18, 2005 |
| Priority date | — |
| Expiry date | Sep 14, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/1288
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.