Method for muscle delivery of drugs, nucleic acids and other compounds
US6958060B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2003 |
| Grant date | Oct 25, 2005 |
| Priority date | — |
| Expiry date | Aug 3, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/36017
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.