Variants of Erwinia-type creatinase

US6958231B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Zhixin Shao
• Rainer Schmuck · Benediktbeuern, DE
• Peter Kratzsch · Penzberg, DE
• Janet Kenklies · Penzberg, DE
• Harald Weisser · Bernried, DE

Key dates

• Filing date: Sep 20, 2002
• Grant date: Oct 25, 2005
• Expiry date: Dec 31, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/78
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to mutated genes encoding variants of an Erwinia-type creatinase (EC 3.5.3.3, alternative name: creatine amidinohydrolase), to the creatinase variants encoded by these genes, and to different applications of these variants of creatinase, particularly to their use for determining the creatinine and/or creatine concentration in a sample.