Inhibition of major groove DNA binding proteins by modified polyamides
US6958240B1 · kind B1 · utility
14Cited by
7References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 12, 1999 |
| Grant date | Oct 25, 2005 |
| Priority date | — |
| Expiry date | Jul 1, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides improved polyamides comprising a positive patch for contacting the phosphate backbone or major groove of a DNA molecule. As such, the improved polyamides are capable of inhibiting the function or binding of a DNA-binding protein to a DNA molecule. The improved polyamide provides for more efficient function of the polyamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.