Patent · US Expired

Isolation, characterization, cloning and use of a mushroom lectin

US6958321B2 · kind B2 · utility

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6Claims

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Assignee

THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

Irwin Goldstein · Ann Arbor, US
Harry Winter · Ann Arbor, US
Robert P. Kruger · Ann Arbor, US

Key dates

Filing date	May 2, 2002
Grant date	Oct 25, 2005
Priority date	—
Expiry date	May 19, 2023

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The isolation, characterization, cloning and expression of the lectin (agglutinin) from Marasmius oreades (MOA) is described. MOA displays unique carbohydrate binding properties, including blood group B-specific agglutination and preferential binding to Ga1α1,3Ga1-containing sugar epitopes, including but not limited to Ga1α1,3Ga1β1,4G1cNAc. MOA is contemplated as an affinity reagent, a therapeutic in the treatment of antibiotic-induced diarrhea and the field of xenotransplantation. MOA may also serve as a diagnostic reagent, e.g. for malaria.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.