Lactams substituted by cyclic succinates as inhibitors of A-β protein production
US6958329B2 · kind B2 · utility
16Cited by
23References
72Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 4, 2002 |
| Grant date | Oct 25, 2005 |
| Priority date | — |
| Expiry date | Nov 4, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.