4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein

US6958346B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Stoltefuss · Haan, DE
• Michael Logers · Wuppertal, DE
• Gunter Schmidt · Houghton, US
• Arndt Brandes · Wuppertal, DE
• Carsten Schmeck · Wuppertal, DE
• Klaus-Dieter Bremm · Recklinghausen, DE
• Hilmar Bischoff · Wuppertal, DE
• Delf Schmidt · Wuppertal, DE

Key dates

• Filing date: Oct 31, 2001
• Grant date: Oct 25, 2005
• Expiry date: Jan 2, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.