Guanidine mimics factor Xa inhibitors

US6958356B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Patrick Lam · Chadds Ford, US
• Charles G. Clark · Cherry Hill, US
• Celia Dominguez · Los Angeles, US
• John M. Fevig · McKeesport, US
• Amy Han · Hockessin, US
• Renhua Li · Wilmington, US
• Donald J. P. Pinto · Kennett Square, US
• James R. Pruitt · Landenberg, US
• Mimi L. Quan · Newark, US

Key dates

• Filing date: Mar 13, 2002
• Grant date: Oct 25, 2005
• Expiry date: Oct 25, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.