Polypeptides containing γ-amino acids
US6958384B2 · kind B2 · utility
15Cited by
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26Claims
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Key dates
| Filing date | Mar 14, 2003 |
| Grant date | Oct 25, 2005 |
| Priority date | — |
| Expiry date | Mar 14, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained γ-amino acid residue. The compounds have the formula where A is a hydrogen, hydroxy, amino- or carboxy-protecting group, Y is a single bond or a prolyl-containing linking group, and X and Y are γ-amino acid residues, provided that one of X or Y is a conformationally-restrained γ-amino acid residue, and “a,” “c,” and “d” are positive integers. The compounds find use as non-enzymatically degradable probes to mimic protein behavior in solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.