Compounds capable of activating cholinergic receptors

US6958399B2 · kind B2 · utility

Assignee

• Targacept, Inc. · US

Inventors

• William Scott Caldwell · Winston-Salem, US
• Gary Maurice Dull · Lewisville, US
• Balwinder Singh Bhatti · Winston-Salem, US
• Srishailkumar B. Hadimani · Winston-Salem, US
• Haeil Park · Nae-myeon, KR
• Jared Miller Wagner · Stillwater, US
• Peter A. Crooks · Lexington, US

Key dates

• Filing date: May 25, 2004
• Grant date: Oct 25, 2005
• Expiry date: Jun 29, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.