Methods of controlling proliferation and differentiation of stem and progenitor cells
US6962698B1 · kind B1 · utility
20Cited by
0References
29Claims
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Key dates
| Filing date | Aug 17, 1999 |
| Grant date | Nov 8, 2005 |
| Priority date | — |
| Expiry date | Aug 17, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing cooper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.