Pharmaceutical compositions

US6962717B1 · kind B1 · utility

Assignee

• DISPHAR INTERNATIONAL BV · NL

Inventors

• Gerald Huber · Plüderhausen, DE
• Peter Gruber · Bottmingen, CH

Key dates

• Filing date: Jan 29, 1999
• Grant date: Nov 8, 2005
• Expiry date: Jan 29, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5073
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 μm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.