Application of glucose transport mutants for production of aromatic pathway compounds
US6962794B2 · kind B2 · utility
13Cited by
5References
25Claims
0Family size
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Key dates
| Filing date | Sep 30, 1997 |
| Grant date | Nov 8, 2005 |
| Priority date | — |
| Expiry date | Apr 26, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/813
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts−/glucose+. Such host cells are capable of transporting glucose without consuming PEP, resulting in conservation of PEP which can be re-directed into the pathway in order to enhance the production of desired compounds along the pathway. Pts−/glucose+ mutants have been shown to be advantageous for the enhanced production of the aromatic amino acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.