P. aeruginosa mucoid exopolysaccharide specific binding peptides
US6962813B2 · kind B2 · utility
13Cited by
10References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | May 21, 2002 |
| Grant date | Nov 8, 2005 |
| Priority date | — |
| Expiry date | Jul 27, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.