Compositions for the treatment of pigmentation disorders and methods for their manufacture
US6964776B2 · kind B2 · utility
0Cited by
1References
49Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2003 |
| Grant date | Nov 15, 2005 |
| Priority date | — |
| Expiry date | Nov 11, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.