Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses

US6964956B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Charles Cywin · Bethel, US
• Zhidong Chen · New Milford, US
• Roman Fleck · Greenwich, US
• Ming-Hong Hao · Chesterfield, US
• Eugene Richard Hickey · Danbury, US
• Weimin Liu · Sandy Hook, US
• Daniel Richard Marshall · Tucson, US
• Peter A. Nemoto · Raritan, US
• Ronald John Sorcek · Bethel, US
• Sanxing Sun · Danbury, US
• Jiang-Ping Wu · Lexington, US
• Tina Morwick · New Milford, US
• Jonathan Emeigh · Gilbertsville, US

Key dates

• Filing date: Jun 3, 2003
• Grant date: Nov 15, 2005
• Expiry date: Jun 3, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G63/916
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.