Fibrin material and method for producing and using the same
US6965014B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 8, 2000 |
| Grant date | Nov 15, 2005 |
| Priority date | — |
| Expiry date | May 8, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti-adhesion barrier. In this invention, thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained, but still controls the clotting time. The mechanical behavior, high-water capacity, and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device, capable of delivering proteins, hormones, enzymes, antibiotics, antineoplastic agents and even cells for local and systemic treatment of human and non-human patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.