Method for Raman chemical imaging of endogenous chemicals to reveal tissue lesion boundaries in tissue
US6965793B2 · kind B2 · utility
31Cited by
19References
47Claims
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Key dates
| Filing date | Jun 28, 2002 |
| Grant date | Nov 15, 2005 |
| Priority date | — |
| Expiry date | Nov 24, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/65
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Apparatus and methods for spatially resolved Raman detection of molecules indicative of the borders of lesions with normal tissue are disclosed. A region of biological tissue was illuminated with monochromatic light. A Raman shifted light signal is detected from endogenous molecules in the region, the molecules being spatially organized in a localized first area of the region. These molecules are indicative of a border between normal tissue and a lesion. The Raman shifted light signal is then spatially resolved in at least one direction.
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