Methods for modulating nuclear receptor coactivator binding

US6965850B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• John D. Baxter · West Melbourne, US
• Beatrice Diana DARIMONT · San Diego, US
• Weijun Feng · Danville, US
• Robert Fletterick · Hillsborough, US
• Peter J. Kushner · San Francisco, US
• Richard L. Wagner · San Francisco, US
• Brian West · San Francisco, US
• Keith R. Yamamoto · San Francisco, US

Key dates

• Filing date: Mar 30, 1999
• Grant date: Nov 15, 2005
• Expiry date: Mar 30, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.