Production of pancreatic islet cells and delivery of insulin
US6967019B2 · kind B2 · utility
1Cited by
7References
21Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 20, 2001 |
| Grant date | Nov 22, 2005 |
| Priority date | — |
| Expiry date | Jul 24, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the production of islet cells and insulin in a subject by providing for expression of an islet transcription factors in the pancreas of the subject, by for example, introduction of nucleic acid encoding the transcription factor neurogenin3 or a factor that induces neuorgenin3 expression. The present invention also relates to methods for using a islet transcription factor gene and the islet transcription factor polypeptide to alter cellular differentiation in culture or in vivo to produce new β-cells to treat patients with diabetes mellitus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.