Patent · US Expired

Human medical treatment by aerosol inhalation of immunoglobulin A

US6967106B2 · kind B2 · utility

10Cited by
6References
9Claims
0Family size

Inventor

Key dates

Filing dateSep 18, 2002
Grant dateNov 22, 2005
Priority date
Expiry dateOct 17, 2023

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/21
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Pooled human plasma is processed by cold ethanol fractionation to produce purified immunoglobulin G antibodies for intravenous administration. Immunoglobulin A is an unwanted by-product since intravenous administration of immunoglobulin A-containing immunoglobulin G can cause life-threatening anaphylaxis in some people. The present invention is the topical application of immunoglobulin A coupled with J chain, and optionally coupled with secretory component in order to render the immunoglobulin A more physiologically active, for the prevention or treatment of ocular diseases including ocular immune deficiency and infections. Antigen-specific monoclonal immunoglobulin A may be used.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.