Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6972013B1 · kind B1 · utility
218Cited by
4References
24Claims
0Family size
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Key dates
| Filing date | Aug 30, 2002 |
| Grant date | Dec 6, 2005 |
| Priority date | — |
| Expiry date | Mar 12, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/306
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.