Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
US6972124B2 · kind B2 · utility
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Key dates
| Filing date | Nov 7, 2003 |
| Grant date | Dec 6, 2005 |
| Priority date | — |
| Expiry date | Jan 23, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.