Regulated transcription of targeted genes and other biological events

US6972193B1 · kind B1 · utility

Assignees

• Board of Trustees of the Leland Stanford Junior University · US
• President and Fellows of Harvard College · US

Inventors

• Gerald R. Crabtree · Woodside, US
• Stuart L. Schreiber · Cambridge, US
• David Spencer · Houston, US
• Thomas J. Wandless · Cambridge, US
• Steffan N. Ho · San Diego, US
• Peter Belshaw · Madison, US

Key dates

• Filing date: Dec 17, 1999
• Grant date: Dec 6, 2005
• Expiry date: Dec 17, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins.