Carboxylic acid derivatives that inhibit the binding of integrins to their receptors

US6972296B2 · kind B2 · utility

Assignee

• Encysive Pharmaceuticals, Inc. · US

Inventors

• Ronald J. Biediger · Houston, US
• Qi Chen · Irvine, US
• E. Radford Decker · Houston, US
• George W. Holland · North Caldwell, US
• Jamal Kassir · Houston, US
• Wen Li · Taipei, TW
• Robert V. Market · Friendswood, US
• Ian L. Scott · Monroe, US
• Chengde Wu · Shanghai, CN
• Jian Li · Shanghai, CN

Key dates

• Filing date: Oct 9, 2001
• Grant date: Dec 6, 2005
• Expiry date: Oct 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which α4β1 is involved.