Neutral-cationic lipid for nucleic acid and drug delivery
US6974589B1 · kind B1 · utility
11Cited by
6References
22Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 10, 2000 |
| Grant date | Dec 13, 2005 |
| Priority date | — |
| Expiry date | Oct 10, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A lipid represented by the formula: wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH2—, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.