Fourier transform mass spectrometry of complex biological samples

US6974702B2 · kind B2 · utility

Assignee

• Esperion Therapeutics, Inc. · US

Inventors

• Jean-Louis Dasseux · Mannheim, DE
• Roger Schofield Newton · Maple City, US
• Thomas J. Rea · Gregory, US
• Charles L. Bisgaier · Ann Arbor, US
• Michael Pape · Stade, DE

Key dates

• Filing date: Sep 8, 2003
• Grant date: Dec 13, 2005
• Expiry date: Sep 8, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).