Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses

US6974870B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Charles Cywin · Bethel, US
• Can Mao · Philadelphia, US
• Jonathan Emeigh · Gilbertsville, US
• Roman Fleck · Greenwich, US
• Ming-Hong Hao · Chesterfield, US
• Eugene Richard Hickey · Danbury, US
• Weimin Liu · Sandy Hook, US
• Daniel Richard Marshall · Tucson, US
• Tina Morwick · New Milford, US
• Peter A. Nemoto · Raritan, US
• Ronald John Sorcek · Bethel, US
• Sanxing Sun · Danbury, US
• Jiang-Ping Wu · Lexington, US
• Erick Richard Roush Young · Danbury, US
• Darren DiSalvo · New Milford, US
• John David Ginn · New Milford, US
• Pier Francesco Cirillo · Woodbury, US

Key dates

• Filing date: Dec 6, 2003
• Grant date: Dec 13, 2005
• Expiry date: Dec 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.