Circular DNA molecule with conditional origin of replication, method for preparing the same and use thereof in gene therapy
US6977174B2 · kind B2 · utility
14Cited by
14References
102Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 13, 1996 |
| Grant date | Dec 20, 2005 |
| Priority date | — |
| Expiry date | Oct 18, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterized in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.