Chimaeric plant viruses with mucin peptides
US6979448B1 · kind B1 · utility
0Cited by
5References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 11, 2000 |
| Grant date | Dec 27, 2005 |
| Priority date | — |
| Expiry date | Jul 23, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/18022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mucin peptide epitopes are inserted into the coat protein of a plant virus (e.g., a comovirus such as CPMV) having a beta-barrel structure at an immunogenically effective site, such as in a loop connecting beta sheets or at/near the C-terminus. The resulting chimaeric virus particles are extremely immunogenic, giving better results than KLH conjugation and not requiring the addition of exogenous adjuvant. They are effective at mucosal surfaces, particularly when administered intranasally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.