Compositions and methods for inhibiting inward-rectifier potassium channels
US6979572B1 · kind B1 · utility
2Cited by
1References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 7, 1999 |
| Grant date | Dec 27, 2005 |
| Priority date | — |
| Expiry date | Jul 7, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides compounds and methods of identifying and designing compounds which inhibit activity of inward-rectifier K+ channels. In particular, compounds having a tertiapin-like α helix, such as a stable tertiapin derivative wherein the methionine residue in position 13 of tertiapin is replaced by glutamine, are described. Methods of using these compounds to control insulin secretion, and cardiac rhythm and electrical conduction, to modulate neurotransmissions of neurons, and to induce diuresis in mammals are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.