Half-sandwich ruthenium (II) compounds comprising nitrogen containing ligands for treatment of cancer

US6979681B2 · kind B2 · utility

Assignee

• The University Court of the University of Edinburgh · GB

Inventors

• Robert E. Morris · Banff, CA
• Peter John Sadler · Wymondham, GB
• Haimei Chen · Edinburgh, GB
• Duncan Jodrell · Edinburgh, GB

Key dates

• Filing date: May 18, 2004
• Grant date: Dec 27, 2005
• Expiry date: May 18, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F17/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ruthenium (II) compounds of the formula: wherein: R1 is —CO2CH3; R2, R3, R4, R5 and R6 independently represent H, alkyl, cylcoalkyl, —CO2R′, aryl or alkylaryl, which latter two groups are optionally substituted on the aromatic ring; R′ represents alkyl, cylcoalkyl, aryl or alkaryl; X is halo, H2O, (R′)(R″)SO, R′CO2− or (R′)(R″)C═O, where R″ represents alkyl, cylcoalkyl, aryl or alkaryl; Y is a counterion; m is 0 or 1; q is 1, 2 or 3; C′ is C1 to C12 alkylene, optionally substituted in or on the alkylene chain, bound to two A groups; p is 0 or 1 and r is 1 when p is 0 and r is 2 when p is 1; and A and B are: each independently R11—CN, where R″ represents alkyl or cycloalkyl; or B is halo and A is 4-substitued pyridine; or p is 0, A is NR7R8 and B is NR9R10wherein R7, R8, R9 and R10 independently represent H, or alkyl, and A and B are linked by an alkylene chain, optionally substituted in or on the alkylene chain; or p is 1, A is NR7 and B is NR9R10, wherein R7, R9 and R10 are as previously defined, and A and B are linked by an alkylene chain, optionally substituted are described.