Compounds capable of activating cholinergic receptors

US6979695B2 · kind B2 · utility

Assignee

• Targacept, Inc. · US

Inventors

• William Scott Caldwell · Winston-Salem, US
• Gary Maurice Dull · Lewisville, US
• Balwinder Singh Bhatti · Winston-Salem, US
• Srishailkumar B. Hadimani · Winston-Salem, US
• Haeil Park · Nae-myeon, KR
• Jared Miller Wagner · Stillwater, US
• Peter A. Crooks · Lexington, US
• Patrick M. Lippiello · Clemmons, US
• Merouane Bencherif · Winston-Salem, US

Key dates

• Filing date: Oct 2, 2002
• Grant date: Dec 27, 2005
• Expiry date: Nov 24, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.