Process for preparation of ring-substituted 8-aminoquinoline analogs as antimalarial agents

US6979740B2 · kind B2 · utility

Assignee

• NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER) · IN

Inventors

• Rahul Jain · Kanchinakote, IN
• Meenakshi Jain · Nakodar, IN
• Prati Pal Singh · Nakodar, IN
• Sacita Singh · Nakodar, IN
• Sandeep Sachdeva · Nakodar, IN
• Vijai Misra · Nakodar, IN
• Poduri Ramarao · Nakodar, IN
• Chaman Kaul · Nakodar, IN
• Kulbhushan Tikoo · Nakodar, IN

Key dates

• Filing date: Dec 15, 2003
• Grant date: Dec 27, 2005
• Expiry date: Jan 14, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is concerned with the development of novel 8-aminoquinoline analogs in the treatment and prevention of malaria and the said compound has broad spectrum of activity against the blood as well as tissue stages of the human malaria parasites makes these compounds very attractive in the cure and prevention of malaria caused by drug-sensitive and multidrug resistant strains and also it is expected that development of these compounds as ideal antimalarial agents may lead to suppression as well as radical cure of the malaria infection with single drug therapy.