Compositions, methods and kits relating to thrombin degradation resistant fibroblast growth factor-1
US6982170B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 17, 2001 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Dec 17, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/501
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to novel degradation resistant FGF-1, and methods for producing and using the same. More specifically, the invention relates to identification of a thrombin degradation resistant FGF-1, an a nucleic acid encoding the same. The thrombin degradation resistant FGF-1 can elicit responses that are otherwise typically impeded by degradation of FGF-1 by thrombin. Thrombin degradation resistant FGF-1 is an important molecule for effecting an FGF-1 response that would be otherwise inhibited by thrombin. Thus, the present invention provides a powerful therapeutic for diseases or disorders wherein an FGF-1 response can mediate a reduction in the frequency or intensity of a symptom of the disease or disorder but for degradation of FGF-1 before it can effect the response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.