Nitriles useful as reversible inhibitors of cysteine proteases
US6982263B2 · kind B2 · utility
1Cited by
13References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 4, 2002 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Jan 21, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions exacerbated by these proteases such as, but not limited to, osteoporosis, rheumatoid arthritis, multiple sclerosis, asthma and other autoimmune diseases, Alzheimer's disease, atherosclerosis. Also disclosed are processes for making such novel compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.