Substituted alcohols useful in treatment of Alzheimer's disease
US6982264B2 · kind B2 · utility
17Cited by
133References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 27, 2002 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Jul 29, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.