Compounds useful as reversible inhibitors of cysteine proteases

US6982272B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Michel Jose Emmanuel · New Fairfield, US
• Eugene Richard Hickey · Danbury, US
• Weimin Liu · Sandy Hook, US
• Denice Spero · West Redding, US
• Sanxing Sun · Danbury, US
• David Thomson · Ridgefield, US
• Yancey David Ward · Sandy Hook, US
• Erick Richard Roush Young · Danbury, US

Key dates

• Filing date: Apr 24, 2003
• Grant date: Jan 3, 2006
• Expiry date: Dec 14, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.