Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists

US6982278B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Dawn Brooks · Indianapolis, US
• Scott Eugene Conner · Elizabethtown, US
• Samuel James Dominianni · Indianapolis, US
• Alexander Godfrey · Greenwood, US
• Lynn Stacy Gossett · Indianapolis, US
• Christopher John Rit · Martinsville, US
• Allie Edward Tripp · Indianapolis, US
• Alan M. Warshawsky · Cincinnati, US
• Leonard Larry Winneroski, Jr. · Greenwood, US
• Guoxin Zhu · Noblesville, US

Key dates

• Filing date: Aug 23, 2001
• Grant date: Jan 3, 2006
• Expiry date: Sep 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (II), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubsituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl. R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.