C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity
US6982317B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2001 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Aug 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.