Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US6982318B1 · kind B1 · utility
16Cited by
3References
11Claims
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Key dates
| Filing date | Mar 24, 2000 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Mar 24, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A class of motif-specific, context-independent antibodies that bind conserved signal transduction motifs, such as kinase consensus substrate motifs and protein-protein binding motifs, containing one or more modified amino acids, such as a phosphorylated amino acid, is provided. The antibodies bind a plurality of peptides or proteins that contain the modified motif. Context-independent antibodies specific for single modified residues, such as phosphothreonine, are also provided. Methods for producing and using such antibodies are provided.
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