Synthesis of chlorinated pyrimidines

US6982331B2 · kind B2 · utility

Assignee

• Syngenta Crop Protection AG · CH

Inventors

• Timothy Doyle · Morristown, US
• Alan Henry Benke · Bucks, US
• Peter K. Wehrenberg · Piedmont, US
• Louie A. Nady · Daphne, US
• Gilbert Rodriguez · El Paso, US

Key dates

• Filing date: Jun 27, 2003
• Grant date: Jan 3, 2006
• Expiry date: Aug 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl2). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. Phosgene may be replaced by equivalent reagents. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.