Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
US6982351B2 · kind B2 · utility
19Cited by
44References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 6, 2002 |
| Grant date | Jan 3, 2006 |
| Priority date | — |
| Expiry date | Dec 6, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.