Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof

US6984486B1 · kind B1 · utility

Assignee

• THE J. DAVID GLADSTONE INSTITUTES · US

Inventors

• Ulrich Schubert · Jena, DE
• Peter Henklein · Belfast, GB
• Victor Wray · Braunschweig, DE

Key dates

• Filing date: Feb 19, 2000
• Grant date: Jan 10, 2006
• Expiry date: Feb 19, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/81
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention pertains to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr1-96), of a 47 amino acid long N-terminal (sVpr1-47), of a 49 amino acid long C-terminal fragment (sVpr48-96) as well as fragments thereof (sVpr1-20 and sVpr21-40) and further approximately 15 amino acid long fragments of sVpr1-96. As fragments or full length products of the HIV-1 regulatory protein, those products are used in biological assays, for molecular and structural characterization of Vpr and domains thereof, as well as for the development of anti-Vpr antibodies directed against Vpr peptide sequences.