Anaerobe targeted enzyme-mediated prodrug therapy

US6984513B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• John Martin Brown · Redwood City, US
• Shie-Chau Liu · Redwood City, US
• Amato J. Giaccia · Stanford, US
• Nigel P. Minton · Salisbury, GB

Key dates

• Filing date: May 31, 2002
• Grant date: Jan 10, 2006
• Expiry date: Aug 19, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described.